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Naturalizer Naturalizer Marianne women's Naturalizer Marianne Marianne Marianne Naturalizer women's women's waOSx7q
Description
For men looking for basic quality, this cardigan designed by Scotch & Soda is for you. Worn with a pair of jeans for a dazzling finish!
Information

The model measures 181cm and wears a size EU M.

Closure :

   Zip fastening

Composition :

   Wool : 85%

   Acrylic : 15%

Care advice :

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Applications
constitutional
Catalogue Numbers
LPE NOR (10 tests)
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LPE NOR-S (5 tests)

The Nucleolar Organiser Regions (NOR) contain clusters of genes which code for the three largest structural rRNA molecules (5.8S, 18S and 28S).

These rRNA genes are critically important for the viability of the cell and represent around 0.5% of the human diploid genome. They are found in the short arm of the acrocentric chromosomes and are the region around which the nucleoli develop at the end of mitosis1.

A NOR can translocate to a terminal region of another chromosome. In rare instances this can be pathogenic, particularly when the translocation has led to a deletion at the tip of the recipient chromosome2. It has been suggested that the restructuring of the rRNA genes is the most common chromosomal alteration in adult solid tumours3.

In routine cytogenetic analysis, NOR can be used to delineate marker chromosomes through a process of silver staining the NOR (known as AgNOR staining4). However, the technique relies on translation of protein and if this is not present, conventional silver staining will not stain the NOR. Cytocell's FISH probe has been developed to overcome this problem so that presence of the acrocentric chromosomes in the marker can be detected.

In our hands, Cytocell FISH probes, have proven to be of the highest quality with bright, easy to interpret signals, thus providing confidence in our results. Cytocell’s customer support is outstanding, as their staff are extremely knowledgeable and truly care about their customers and their customers’ needs.  Jennie Thurston, Director of Cytogenetics at Carolinas Pathology Group

Sango Sango Sango Grey Grey Grey References

1. McClintock B, Z Zellforsch Mikrosk Anat 1934;21:294-328

Grey Grey Grey Sango Sango Sango 2. Gardner RJM, Grant R Sutherland, Chromosome abnormalities and genetic counseling, Oxford University Press p240 2004

3. Stults DM et al., Cancer Res 2009;69(23):9096-104

4. Goodpasture C, Bloom SE, Chromosoma 1975;53:37-50

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Disclaimer

This product is intended to be used on Carnoy’s solution (3:1 methanol/acetic acid) fixed peripheral blood samples.

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